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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway

Fig. 2

Glioblastoma-derived EVs elevate the migration of glioblastoma cells. A U87-EVs-treated U87 cells showed higher numbers of migrated cells than DMSO-treated cells in transwell assay. GW4869 largely reduced the number of migrated cells. The addition of U87-EVs to GW4869-treated cells significantly reversed GW4869-induced reduction of migrated cells. B A172-EVs did not alter the numbers of migrated A172 cells in transwell assay. GW4869 largely reduced the number of migrated cells. The addition of A172-EVs to GW4869-treated cells significantly reversed GW4869-induced reduction of migrated cells. C LN229-EVs-treated LN229 cells showed higher numbers of migrated cells than DMSO-treated cells in transwell assay. GW4869 largely reduced the number of migrated cells. The addition of LN229-EVs to GW4869-treated cells significantly reversed GW4869-induced reduction of migrated cells. Results are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. Scale bar, 100 μm (A, B, C) and 200 μm (D, E, F)

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Cell Communication and Signaling

ISSN: 1478-811X