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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Single-cell analysis reveals cell communication triggered by macrophages associated with the reduction and exhaustion of CD8+ T cells in COVID-19

Fig. 5

Functional heterogeneity of macrophage subpopulations after SARS-CoV-2 infection. a–c Differences in pathway activities scored per macrophages by GSVA with Moderate vs. Control (a), Severe vs. Control (b), Severe vs. Moderate (c). d Heatmap of GSVA score of top 25 signal pathway for each macrophage across conditions. the value for each GSVA score is row-scaled. e, f Signal pathway activity of glycolysis (e) and oxidative phosphorylation (f) under hypoxia status across macrophage subtypes. * p < 0.05, ** p < 0.01 (Student’s t test)

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Cell Communication and Signaling

ISSN: 1478-811X