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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells

Fig. 3

Inhibition of HSP90AB1 induces nuclear localization of Bcr-Abl in CML cells. a The concentration of HSP90 inhibitor 17AAG on CML cells was screened by Cell Counting Kit-8 experiment. *p < 0.05, **p < 0.01 and ***p < 0.001. b The changes of Bcr-Abl localization in K562 cells treated with HSP90 inhibitor 17AAG were observed by indirect immunofluorescence. c The changes of Bcr-Abl localization in K562 cells treated with HSP90 inhibitor 17AAG and protein nuclear export inhibitor LMB were observed by indirect immunofluorescence. d, e The changes of Bcr-Abl protein expression in cytoplasm and nucleus of K562 and K562/G01 cells treated with HSP90 inhibitor 17AAG were observed by western blot analyses

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Cell Communication and Signaling

ISSN: 1478-811X