Fig. 4

Cell structures critical for epithelial homeostasis and regulated by the interface of SFKs and actin cytoskeleton regulatory complexes. Loss of integrity the structures and /or deregulation of these complexes promote EMT. Top left, Major cell adhesion and invasive phenotypes mediated by SFKs critical for the epithelial to mesenchymal transition. Top right, Cell–cell adhesion, with adherens junctions regulated by E-cadherin, catenins, p120. WAVE complex regulates actin cytoskeleton input into adherence junctions with ABI1 being a key adaptor protein for SRC at the membrane (see text for more details). Lower left, Active SRC regulates FAK to maintain and regulate integrin function. Integrins are intimately involved in cell migration, invasive potential and tissue specificity during metastasis. Lower right, a key complex that regulates invadopodia through SRC-Arg and SRC-Tsk5 axes: N-WASp, Arp2/3, cortactin and control actin polymerization input in invadopodia. MMP2 and MMP9 degrade collagen and other ECM integral proteins. Created with BioRender.com