Fig. 1
From: Methylation as a key regulator of Tau aggregation and neuronal health in Alzheimer’s disease
Lysine-directed Post translational modifications of Tau. Tau protein can be subjected to many post-translational modifications owing to its unfolded structure. Tau undergoes post-translational modifications like phosphorylation, acetylation, methylation, etc. which determines its functional state in neurons. Lysine-directed post-translational modifications like acetylation, methylation, ubiquitination and sumoylation also reflects the functional state of Tau as these modifications may compete for a specific lysine residue in Tau with each modification having different effect. For example, ubiquitination marks the protein to direct toward its degradation while other modifications at the same lysine residue may increase its stability