Fig. 3
From: Circadian clock: a regulator of the immunity in cancer
Initiate anti-cancer immunity: releasing of cancer cell antigen, cancer antigen presentation, and priming and activation. Tumor cell death is accompanied by antigen release. Dendritic cells present antigens to naïve T cells. Then, the naïve T cells prime and activate the effector T cells. On the other hand, the antigen can also be presented by TAMs. Additionally, TAMs stimulate Th cells to produce cytokines. The circadian clock components take part in these processes