Fig. 4

Clinical relevance of Phosphoinositides signaling. Different signaling molecules from the phosphoinositides pathway can undergo genetic mutations, which lead to various neurodegenerative diseases. The Kinases and phosphatases from the pathway and the corresponding diseases related to their mutation have been mentioned. Specifically Synptojanin 1 (SYNJ1) and in this figure genes-associated with the phosphatases are known to cause varied neurodegerative conditions, which is also link with Down’s syndrome