Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Hepatitis B virus X protein promotes vimentin expression via LIM and SH3 domain protein 1 to facilitate epithelial-mesenchymal transition and hepatocarcinogenesis

Fig. 6

HBX enhances the stability of vimentin via LASP1. a HBX promoted vimentin stability in hepatoma cells. b HBX inhibited vimentin ubiquitination in hepatoma cells. c HBX promoted LASP1 stability in hepatoma cells. d HBX inhibited LASP1 ubiquitination in hepatoma cells. e HBX promoted vimentin stability through LASP1 in hepatoma cells. f HBX inhibited vimentin ubiquitination through LASP1 in hepatoma cells. Mock: cells transfected with control plasmid. HBX: cells transfected with HBX plasmid. HBX-shCON: HBX-positive cells transfected with shRNA control plasmid. HBX-shLASP1: HBX-positive cells transfected with shRNA plasmid targeting LASP1. *P < 0.05, HepG2-Mock compared to HepG2-HBX, or HepG2-HBX-shCON compared to HepG2-HBX-shLASP1; #P < 0.05, Huh7-Mock compared to Huh7-HBX, or Huh7-HBX-shCON compared to Huh7-HBX-shLASP1

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X