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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Coordinated regulation of immune contexture: crosstalk between STAT3 and immune cells during breast cancer progression

Fig. 1

A schematic depiction of constitutive STAT3 activation in immune cells. The phosphorylation of STAT3 is triggered by tumor-derived factors and genetic stress. The activated STAT3 subsequently translocated to the nuclear, where it binds to the DNA at specific site and leads to increased transcription of target genes, thereby contributing to immune cells generation, polarization and immunosuppression properties

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Cell Communication and Signaling

ISSN: 1478-811X