Fig. 7
From: Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Baicalein-mediated Tau dissolution by SDS-PAGE. a Figure shows the time-dependent SDS-PAGE analysis of Tau aggregates dissolution. After 72 h, the higher concentrations of Baicalein showed a maximum decrease in the aggregates (lane 7, 8, 9 green asterisk) as compared to control (lane 2 red asterisk). b The SDS-PAGE quantification for different time points indicate the initial increase followed by the decrease in the aggregates at the higher concentrations of Baicalein. c Transmission electron micrographs showed the untreated mature fibrils (white arrow) versus disaggregated amorphous (encircled black), Baicalein treated fibrils of full-length Tau. (The statistical analysis was carried out by Student’s unpaired t test with respect to Baicalein untreated control. ***p ≤ 0.001, **p ≤ 0.01, *p ≤ 0.05. ns non-significant p value). Further, post hoc analysis was carried by one-way ANOVA and Tukey’s criterion was determined for honestly significant difference (HSD). The data was considered significant if |X–X′|> Tukey’s criterion