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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

Fig. 8

Schematic of the CYP1A1–12(S)-HETE−JNK − AP-1 and CYP1A1-SR-A signalling pathways in macrophage activation. CYP1A1 is highly upregulated in inflammatory macrophages via multiple transcriptional factors. Activated CYP1A1 promotes the production of 12(S)-HETE via its hydroxylase activity and the 12(S)-HETE produced intensifies JNK/AP-1 phosphorylation, which strongly activates genes encoding inflammatory cytokines. Upregulated CYP1A1 also impeded the phagocytosis of E.coli by macrophages via depressing SR-A expression. Consequently, these results indicated macrophage CYP1A1 as a negative regulator during septic process and demonstrated that Rhapontigenin could be a novel therapeutic agent against sepsis

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Cell Communication and Signaling

ISSN: 1478-811X