Fig. 1

XIAOPI formula suppresses the polarization of M2 macrophages and CXCL1 expression. a The phenotype changes of RAW264.7 induced by 40 ng/ml IL-4 and 40 ng/ml IL-13. b Effects of XIAOPI formula on the proliferation of M1 and M2 phenotype RAW264.7. c The surface marker CD206, CD163 and Arg1 of M2 phenotype were all downregulated dose-dependently under the treatment of XIAOPI formula, while the M1 marker CD86 was upregulated. d XIAOPI formula dose-dependently downregulated CXCL1 transcription in M2 phenotype RAW264.7 cells. e XIAOPI formula dose-dependently inhibited expression of CXCL1 in M2 phenotype RAW264.7 cells. (The results were obtained from triplicate experiments and were represented as mean values ± SD., *P < 0.05, **P < 0.01 as compared with control, ^##P < 0.01, comparison between three time points of 24 h, 48 h, and 72 h)