Fig. 2

Single nucleotide polymorphism (SNP) rs12982687 (C > T) affected binding of UCA1 with miRNAs in colorectal cancer (CRC) cells. a The luciferase activity of CRC cells was compared between allele T + miR-873-5p/miR-1207-5p/miR-584 mimic group and allele C + miR-873-5p/miR-1207-5p/miR-584 mimic group. *: P < 0.05 when compared with allele T + miR-873-5p/miR-1207-5p/miR-584 mimic group. b UCA1 expression was determined when miR-873-5p mimic, miR-873-5p inhibitor or miR-NC was transfected into CRC cells, and miR-873-5p expression was measured among CRC cells of pcDNA3.1, pcDNA3.1-UCA1, si-UCA1 and NC groups. *: P < 0.05 when compared with NC group. c The genotype of rs12982687 (C > T) was determined within SW620 cell line and within SW480 cell line. d Expressional change of HIF-1α in SW620 and SW480 cell lines was determined in case of altered expression of UCA1 and miR-873-5p, and expressions of UCA1 and miR-873-5p were monitored when HIF-1α level was intentionally changed in CRC cells *: P < 0.05 when compared with NC group