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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: F0F1 ATP synthase regulates extracellular calcium influx in human neutrophils by interacting with Cav2.3 and modulates neutrophil accumulation in the lipopolysaccharide-challenged lung

Fig. 6

Inhibition of F-ATPase reduces neutrophil accumulation and reduces lung injury in LPS-induced lung inflammation. Mice were intratracheally instilled with LPS (5 mg/kg body weight) and sacrificed after 24 h. a. Representative images of the lungs of mice from different treatments and corresponding total cells in BALF, which were stained with a Wright-Giemsa stain using cytospin preparations. b. The total number of pulmonary neutrophils in BALF. **P < 0.01 versus the LPS mice. The data are presented as the mean ± s.d (n = 5). c. The lung wet-to-dry ratio was measured 24 h after LPS instillation. *P < 0.05 versus the LPS mice. The data are presented as the mean ± s.d (n = 5). d. Representative hematoxylin and eosin (H&E)-stained images of lung tissues and a corresponding 2x enlarged grid show emigrated neutrophils in the pulmonary parenchyma

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Cell Communication and Signaling

ISSN: 1478-811X