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Table 4 Phosphatases involved in dephosphorylation of NLRP3 inflammasome components

From: Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities

Phosphatase

Activator

Substrate

Dephosphorylation sitea

Domain

Molecular or cellular outcome

Refs.

PP2A

–

NLRP3

S5

PYD

NLRP3 activation

[28]

PTPN22

–

NLRP3

Y861

LRR

NLRP3 activation

[26]

  1. aAmino acid residues shown above refer to human NLRP3
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Cell Communication and Signaling

ISSN: 1478-811X