Table 2 DUBs involved in deubiquitination of NLRP3 inflammasome components
DUBs | Activator | Substrate | Ubiquitylation site | Molecular or cellular outcome | Linkage specificity | Refs. |
|---|---|---|---|---|---|---|
BRCC3 | LPS | NLRP3 | LRR | NLRP3 deubiquitination | unknown | [9] |
USP7 | LPS | NLRP3 | Unknown | NLRP3 deubiquitination | unknown | [8] |
USP47 | LPS | NLRP3 | Unknown | NLRP3 deubiquitination | unknown | [8] |
USP50 | LPS/Nigericin | ASC | Unknown | ASC deubiquitination/positive regulation | K63-linked | [38] |