Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma

Table 1 Associations of RIPK1 and TLR3 expression with clinicopathological parameters of CCA patients

		TLR3		Chi square	p-value	RIPK1		Chi square	p-value
Gender	n (%)	Low	High			Low	High
Male	54 (39%)	22	30	0.103	0.748	26	26	1.059	0.303
Female	35 (61%)	14	22	0.103	0.748	22	14	1.059	0.303
Age (years)
< 67	44 (50%)	19	25	0.188	0.665	28	16	2.933	0.087
> = 67	44 (50%)	17	27	0.188	0.665	20	24	2.933	0.087
Grading
well differentiated	13 (14.8%)	4	11	3.152	0.207	9	6	0.277	0.893
moderately differentiated	73 (83%)	32	39			38	33
poorly differentiated	2 (2.2%)	0	2			1	1
Tumor size (mm)
< 35	30 (38.5%)	14	35	5.727	0.030	27	22	0.119	0.730
> = 35	48 (61.5%)	20	17	5.727	0.030	19	18	0.119	0.730
Perineural Invasion
Present	65 (73%)	22	43	5.132	0.023	43	22	13.517	0.0002
None	24 (27%)	14	9	5.132	0.023	5	18	13.517	0.0002
Vascular Invasion
Present	66 (74.2%)	21	45	9.026	0.003	41	25	6.111	0.013
None	23 (25.8%)	15	7	9.026	0.003	7	15	6.111	0.013
Lymph node invasion
Present	62 (69.7%)	19	43	9.145	0.002	40	22	8.414	0.004
None	27 (30.3%)	17	9	9.145	0.002	8	18	8.414	0.004

ISSN: 1478-811X