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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Receptor-interacting protein kinase 1 is a key mediator in TLR3 ligand and Smac mimetic-induced cell death and suppresses TLR3 ligand-promoted invasion in cholangiocarcinoma

Fig. 7

Schematic diagram of RIPK1 modulated TLR3 ligand, Poly(I:C)-induced cell death and invasion in CCA. a In CCA cells with RIPK1 and TLR3 expression, Smac mimetic and TLR3 ligand, Poly(I:C) induces apoptosis and necroptosis and Smac mimetic reverses Poly(I:C)-induced invasion. b In CCA cells with low RIPK1 expression, Smac mimetic and TLR3 ligand, Poly(I:C)-induced apoptosis and necroptosis are inhibited, while TLR3 ligand, Poly(I:C) enhances invasion. The reversion of Poly(I:C)-induced invasion by Smac mimetic is partly mediated by RIPK1. *Created with BioRender

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Cell Communication and Signaling

ISSN: 1478-811X