Table 1 IC50 values of C212 and curcumin in cancer cell lines (48-h treatment; Cur, curcumin)

Growth% under C212 vs. Cur (p-value)

0.8 μM

1.6E-01

9.7E-03

3.3E-02

9.4E-03

2.8E-02

3.5E-02

1.6 μM

1.1E-03

7.4E-03

3.5E-02

5.6E-04

4.8E-01

4.7E-02

1.7E-01

4.9E-03

3.2 μM

2.3E-07

2.7E-03

1.2E-02

3.3E-04

6.0E-02

2.2E-01

3.2E-01

3.2E-03

6.3 μM

7.0E-05

4.3E-04

1.5E-03

8.1E-04

4.6E-03

4.0E-04

1.3E-03

5.4E-03

12.5 μM

1.2E-03

7.1E-03

3.6E-05

9.5E-03

4.6E-01

1.3E-04

7.3E-04

6.2E-03

IC 50 (μM)

C212

1.2

3.7

3.4

1.9

8.2

6.3

6.7

3.4

Cur

17.6

14.8

11.0

7.1

10.0

12.6

18.9

12.3

C212/Cur

0.07

0.25

0.31

0.27

0.82

0.50

0.36

0.27

0.50

0.36

0.27

AUC

C212

108.1

140.4

145.2

122.1

173.5

164.0

174.7

140.5

Cur

155.5

174.6

173.2

162.9

180.0

179.7

183.4

175.9

C212/Cur

0.70

0.80

0.84

0.75

0.96

0.91

0.95

0.80

0.91

0.95

0.80