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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Constitutively active androgen receptor supports the metastatic phenotype of endocrine-resistant hormone receptor-positive breast cancer

Fig. 1

AR is highly modified in ET-R BCa. a-b High expression of AR correlates with better DMFS for HR+ BCa patients not receiving Tam therapy. Generated plots from KM Plotter database for BCa (www.kmplot.com) illustrate 10-year DMFS for: (a) HR + -BCa and (b) Tam-treated HR + -BCa patients. Plots separate high and low gene expressions. Both HR, representing hazard ratio at 95% confidence, and log-rank P values are enlarged in the dotted box. c Endogenous AR protein is highly modified in long-term estrogen deprived (EDR-7), acquired (TamR-7) and intrinsic TamR-BCa cell lines (GI-101A and GILM2). Blot represents three independent experiments; arrows indicate modified and unmodified AR. d Ginkgolic acid (GA) inhibits SUMO-modification of AR in a dose-dependent manner. TamR-7 cells were treated with increasing concentrations of GA and immunoblot represents two independent experiments

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Cell Communication and Signaling

ISSN: 1478-811X