Fig. 2
From: Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1
Fzd7 contributes to BC cell stemness. a and b Heat maps generated from CCLE database (a) and GSE12777 database (b) demonstrated the correlation of FZD7 with stemness-related genes in human BC cell lines. c Heat map generated from GSE2603 database demonstrated the correlation of FZD7 with stemness-related genes in human BC tissues. d Mammosphere formation in MDA-MB-231 cells transfected with shCtrl or shFZD7 was shown. e Mammosphere formation in MCF7 cells transfected with control vector or FZD7 overexpression vector was shown. f The fraction of Lgr5+ subpopulation in MDA-MB-231 cells transfected with shCtrl or shFZD7 was determined by flowcytometry. g The fraction of Lgr5+ subpopulation in MCF7 cells transfected with control vector or FZD7 overexpression vector was determined by flowcytometry. All experiments were carried out three times. Data are expressed as Mean ± s.e.m