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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR

Fig. 4

The blocking efficacy of TIGIT/PVR interaction by small molecule compounds. a Schematic representation of cell based blocking assay. The TIGIT expression level on CHOK1-hTIGIT cells were confirmed (Left). The representative FACS histogram of tested compounds, cells only incubated with anti-human IgG-PE served as the negative and cells incubated with human PVR-Fc protein served as the positive control (Right). b The dose dependent blocking curves of SMC 6, SMC 14 and SMC 22 were shown. (c and d) The representative FACS histogram of blocking assay of SMC 14 with CHOK1-hTIGIT c and CHOK1-mTIGIT cells d were shown. Data are representative of at least three independent experiments

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Cell Communication and Signaling

ISSN: 1478-811X