Orchestration of signaling by structural disorder in class 1 cytokine receptors

Seiffert, Pernille; Bugge, Katrine; Nygaard, Mads; Haxholm, Gitte W.; Martinsen, Jacob H.; Pedersen, Martin N.; Arleth, Lise; Boomsma, Wouter; Kragelund, Birthe B.

doi:10.1186/s12964-020-00626-6

Cell Communication and Signaling

Table 1 Overview of isoforms of the cytokine class 1 receptor family differing in the ICD

From: Orchestration of signaling by structural disorder in class 1 cytokine receptors

Class 1 Cytokine Receptors with Intracellular Domains
	Name^#	Iso form	Alternative Names	Uniprot Identifier	ICD sequence (Bold: Identical in all ICD isoforms, Italics: Unique sequence)	Residues^a	Unique start	Unique end	ICD length	ICD start
GROUP 1 - HOMODIMERIC RECEPTORS	PRLR	1,2^b	PRLRfl¹ ΔS1²	p16471-1	KGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH	622¹ 521²			364	259
		4	SF1a	p16471-4	KGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGDPLMLGASHYKNLKSYRPRKISSQGRLAVFTKATLTTVQ	376	338	376	118	259
		5	I	p16471-5	KGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQEREQRQAQEARDS	349	337	349	91	259
		6,8^c	SF1b⁶ Δ4-SF1b⁸	p16471-6	KGYSMVTCIFPPVPGPKIKGFDAHLLEVTP	288⁶ 217⁸	286⁶ 215⁸	288⁶ 217⁸	30	259⁶ 188⁸
		9	SF1c	p16471-9	KGYSMVTCIFPPVPGPKIKGFDAHLLEDRLCTPGRCCVSTGLTDLDYSCST	309	286	309	51	259
	GHR	1,4^d	GHRfl¹ GHRd3⁴	p10912-1	SKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP	638¹ 616⁴			351	288¹ 266⁴
		2	GHRtr GHR1-279	p10912-2	SKQQSSSSKD	297	292	297	10	288
		3	GHR1-277	p10912-3	SKQQKEN	294	292	294	7	288
	EPOR	F	FL	p19235-1	SHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS	508			236	273
	EPOR	T	Truncated	p19235-3	SHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQVGGLVVPSVPGLPCFLQPNCRPL	328	306	328	56	273
	TPOR	1	C-mpl-P	p40238-1	RWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP	635			121	515
	TPOR	2	C-mpl-K	p40238-2	RWQFPAHYRYRPRQAGDWRWTRWSRTCKQAFLVRSVTPDLRPPPVRTYGFALPARHLWDSPRLLTL	579	523	579	66	514
GROUP 2 - gp130 FAMILY	LIFR	1		P42702-1	YRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND	1097			239	859
	OSMR (IL-31Rβ)	1	OSMRfl IL-31Rβ	Q99650-1	KSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLLDPGEHYC	979			218	762
	G-CSFR	1	G-CSF-R1	Q99062-1	CCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF	836			188	649
		3	G-CSF-R3	Q99062-3	CCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEELPGPRQGQWLGQTSEMSRALTPHPCVQDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF	863	680	707	215	649
		4	GCSF-R4	Q99062-4	CCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQAGPPRRSAYFKDQIMLHPAPPNGLLCLFPITSVL	783	750	783	134	650
	IL-31Rα (GLMR)	1, 2, 6,12	V3² GPL745¹²	Q8NI17-1¹ Q8NI17-2² Q8NI17-6⁶ 8NI17-12¹²	VAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGYVTCPFRPDCPLGKSFEELPVSPEIPPRKSQYLRSRMPEGTRPEAKEQLLFSGQSLVPDHLCEEGAPNPYLKNSVTAREFLVSEKLPEHTKGEV	732¹ 764² 622⁶ 745¹²			194	539¹ 571² 429⁶ 552¹²
		3,5	v4 v1	Q8NI17-3³ Q8NI17-5⁵	VAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRILKPCSTPSDKLVIDKLVVNFGNVLQEIFTDEARTGQENNLGGEKNGTRILSSCPTSI	662³ 681⁵	639³ 639⁵	649³ 649⁵	111	552³ 571⁵
		9	GPL560, short	Q8NI17-9⁹	VAYGLKKPN	560			9	552
		10	GPL610	Q8NI17-10¹⁰	VAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRIRARYQA	611	593	598	60	552
		11	GLP626	Q8NI17-11¹¹	VAYGLKKPNKLTHLCWPTVPNPAESSIATWHGDDFKDKLNLKESDDSVNTEDRIKGSELGTKLKFKPLISLDCAF	626	593	613	75	552
	IL-6Rβ (gp130)	1,3		P40189-1¹ P40189-3³	NKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ	918¹ 857³			277	641¹ 580³
	IL-12Rβ2	1,3		Q99665-1¹ Q99665-3³	STHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCDSLML	862¹ 776³			221	642¹ 556³
	IL-12Rβ2	2		Q99665-2	STHYFQQKRRHSCPWTGS	659	650	659	18	642
	IL-23R	1	IL23R1	Q5VWK5-1	NRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK	629			253	377
	IL-23R	2, 5, 6,7	IL23R2F2² IL23R2F3⁵ IL23R6 ⁶ IL23R5⁷	Q5VWK5-2² Q5VWK5-5⁵ Q5VWK5-6⁶ Q5VWK5-7⁷	NEELPSINTYFPQNILESHFNRISLLEK	375² 264⁵ 374⁶ 227⁷			28	348² 237⁵ 347⁶ 200⁷
	IL-27R	1		Q6UWB1-1	SGRCYHLRHKVLPRWVWEKVPDPANSSSGQPHMEQVPEAQPLGDLPILEVEEMEPPPVMESSQPAQATAPLDSGYEKHFLPTPEELGLLGPPRPQVLA	636			98	539
	IL-12Rβ1	1	Long	P42701-1	GLNRAARHLCPPLPTPCASSAIEFPGGKETWQWINPVDFQEEASLQEALVVEMSWDKGERTEPLEKTELPEGAPELALDTELSLEDGDRCKAKM	662			94	569
	IL-12Rβ1	2	Short	P42701-2	GLNRAARHLCPPLPTPCASSAIEFPGGKETWQWINPVDFQEEASLQEALVVEMSWDKGERTEPLEKTELPEGAPELALDTELSLEDGDRCDR	660	659	660	92	569
	LEPR (OBR)	B	13.2, OBRb	P48357-1	SHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFASYMPQFQTCSTQTHKIMENKMCDLTV	1165			303	863
		A	6.4, HuB219.3	P48357-2	SHQRMKKLFWEDVPNPKNCSWAQGLNFQKRTDIL	896	892	896	34	863
		C	12.1 OBRa	P48357-3	SHQRMKKLFWEDVPNPKNCSWAQGLNFQKMLEGSMFVKSHHHSLISSTQGHKHCGRPQGPLHRKTRDLCSLVYLLTLPPLLSYDPAKSPSVRNTQE	958	892	958	96	863
		D	Hub219.2	P48357-4	SHQRMKKLFWEDVPNPKNCSWAQGLNFQKKMPGTKELLGGGWLT	906	892	906	44	863
GROUP 3 – SOLUBLE ALFA CHAINS	IL-6Rα	1	Long	P08887-1	RFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR	468			82	387
	IL-11Rα	HCR1	Membrane Form	Q14626-1	WLRLRRGGKDGSPKPGFLASVIPVDRRPGAPNL	422			33	390
	IL-11Rα	HCR2	Soluble Form, sIL11RA	Q14626-2	W	390			1	390
GROUP 4 – SLONG CHAIN RECEPTOR CHAINS	IL-7Rα	1	H20	P16871-1	WKKRIKPIVWPSLPDHKKTLEHLCKKPRKNLNVSFNPESFLDCQIHRVDDIQARDEVEGFLQDTFPQQLEESEKQRLGGDVQSPNCPSEDVVITPESFGRDSSLTCLAGNVSACDAPILSSSRSLDCRESGKNGPHVYQDLLLSLGTTNSTLPPPFSLQSGILTLNPVAQGQPILTSLGSNQEEAYVTMSSFYQNQ	459			196	264
	IL-7Rα	3	H1	P16871-2	WKKRIKPIVWPSLPDHKKTLEHLCKKPRKVSVFGA	298	293	298	35	264
	IL-9Rα	1,2		Q01113-1¹ Q01113-2²	KLSPRVKRIFYQNVPSPAMFFQPLYSVHNGNFQTWMGAHGAGVLLSQDCAGTPQGALEPCVQEATALLTCGPARPWKSVALEEEQEGPGTRLPGNLSSEDVLPAGCTEWRVQTLAYLPQEDWAPTSLTRPAPPDSEGSRSSSSSSSSNNNNYCALGCYGGWHLSALPGNTQSSGPIPALACGLSCDHQGLETQQGVAWVLAGHCQRPGLHEDLQGMLLPSVLSKARSWTF	521¹ 500²			230	292¹ 271²
	IL-9Rα	3		Q01113-3	KLSPRLGWGPTGPVCC	342	332	342	16	327
	IL-2Rβ (IL-15R_β)	1		P14784	NCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV	551			286	266
	IL-21R	1		Q9HBE5	KTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS	538			283	256
	IL-4Rα	1,3		P24394-1¹ P24394-3³	CYVSITKIKKEWWDQIPNPARSRLVAIIIQDAQGSQWEKRSRGQEPAKCPHWKNCLTKLLPCFLEHNMKRDEDPHKAAKEMPFQGSGKSAWCPVEISKTVLWPESISVVRCVELFEAPVECEEEEEVEEEKGSFCASPESSRDDFQEGREGIVARLTESLFLDLLGEENGGFCQQDMGESCLLPPSGSTSAHMPWDEFPSAGPKEAPPWGKEQPLHLEPSPPASPTQSPDNLTCTETPLVIAGNPAYRSFSNSLSQSPCPRELGPDPLLARHLEEVEPEMPCVPQLSEPTTVPQPEPETWEQILRRNVLQHGAAAAPVSAPTSGYQEFVHAVEQGGTQASAVVGLGPPGEAGYKAFSSLLASSAVSPEKCGFGASSGEEGYKPFQDLIPGCPGDPAPVPVPLFTFGLDREPPRSPQSSHLPSSSPEHLGLEPGEKVEDMPKPPLPQEQATDPLVDSLGSGIVYSALTCHLCGHLKQCHGQEDGGQTPVMASPCCGCCCGDRSSPPTTPLRAPDPSPGGVPLEASLCPASLAPSGISEKSKSSSSFHPAPGNAQSSSQTPKIVNFVSVGPTYMRVS	825¹ 810³			575	251¹ 236³
	βc	1,2	IL-3Rb	P32927-1¹ P32927-2²	RFCGIYGYRLRRKWEEKIPNPSKSHLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVSPLTIEDPKHVCDPPSGPDTTPAASDLPTEQPPSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSRSLPDILGQPEPPQEGGSQKSPPPGSLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQGAAGSPSLESGGGPAPPALGPRVGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFTPNSGASSVSLVPSLGLPSDQTPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSPRNNPVPPEAKSPVLNPGERPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPSSPGPGPEIKNLDQAFQVKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC	897¹ 903²			437	461¹ 467²
GROUP 5 – SHORT TAIL RECEPTOR CHAINS	CRLF2	1,3	TLSP-R IL-XR	Q9HC73-1¹ Q9HC73-3³	KLWRVKKFLIPSVPDPKSIFPGLFEIHQGNFQEWITDTQNVAHLHKMAGAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEKEASGGSLQLPHQPLQGGDVVTIGGFTFVMNDRSYVAL	371¹ 259³			119	253¹ 141³
	γc	1,2	IL-2Rg	P31785-1¹ P31785-2²	ERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET	369¹ 179²			86	284¹ 94²
	IL-13Rα1	1	IL-13RA1	P78552-1	KRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQTKEETDSVVLIENLKKASQ	427			60	368
	IL-13Rα2	1	IL-13RA2	Q14627-1	RKPNTYPKMIPEFFCDT	380			17	364
	IL-5Rα	1,5		Q01344-1¹ Q01344-5⁵	CKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKPGVETLEDSVF	420¹ 211⁵			59	362¹ 153⁵
	IL-5Rα	4		Q01344-4	CKIKLGPVRRKLKSSVI	378	265	378	17	362
	GM-CSFRα	1, 7, 8	GMRα	P15509-1¹ P15509-7⁷ P15509-8⁸	KRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT	400¹ 434⁷ 267⁸			54	347¹ 381⁷ 214⁸
	GM-CSFRα	2		P15509-2	KRFLRIQRLFPPVPQIKDKLNDNHEVEDEMGPQRHHRCGWNLYPTPGPSPGSGSSPRLGSESSL	410	376	410	64	347
	IL-3Rα	1 + 2	SP1¹ SP2²	P26951-1¹ P26951-2²	RRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT	378¹ 300²			53	326¹ 248²

#Full names of receptors are: PRLR prolactin receptor; GHR growth hormone receptor; EPOR erythropoietin receptor; TPOR thrombopoietin receptor; (alternative name: myeloproliferative leukemia protein, MPL); LIFR leukemia inhibitory factor receptor; OSMR oncostatin-M-specific receptor subunit beta (alternative name: IL-31 receptor subunit beta); G-CSFR granulocyte colony-stimulating factor receptor; IL-31Rα, interleukin-31 receptor subunit alpha (alternative name: GLMR, Gp130-like monocyte receptor); IL-6Rβ interleukin 6 receptor beta (alternative name: gp130, glycoprotein 130); IL-12Rβ2 interleukin 12 receptor beta 2; IL-23R interleukin 23 receptor; IL-27R interleukin 27 receptor; IL-12Rβ1 interleukin 12 receptor beta 1; LEP-R leptin receptor (alternative name OB-R, obesity receptor); IL-6Rα interleukin 6 receptor alpha; IL-11Rα interleukin 11 receptor alpha; IL-7Rα interleukin 7 receptor alpha; IL-9Rα interleukin 9 receptor alpha; IL-2Rβ interleukin 2 receptor subunit beta (alternative name; IL-15Rβ, interleukin-15 receptor subunit beta); IL-21R interleukin 21 receptor; IL-4Rα interleukin 4 receptor alpha; βc cytokine receptor common subunit beta; CRLF2 cytokine receptor-like factor 2 (alternative name TSLPR, thymic stromal lymphopoietin protein receptor); γc cytokine receptor common subunit gamma (alternative name IL-2Rγ interleukin 2 receptor subunit gamma); IL-13Rα1 interleukin 13 receptor alpha 1; IL-13Rα2 interleukin 13 receptor alpha 2; IL-5Rα interleukin 5 receptor alpha; GM-CSFRα granulocyte-macrophage colony-stimulating factor receptor subunit alpha; IL-3Rα interleukin 3 receptor subunit alpha
^aResidue numbering is with the signal peptide included
^bIsoform 2: missing residues 24–124, but ICD is identical
^cSF1b, Isoform 8 missing 1–71 ICD identical to Isoform 6
^dIsoform 4: A24D & 25–46 missing, but ICD is identical

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ISSN: 1478-811X

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