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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone

Fig. 1

Schematic interpretation of the GPCR-mediated signaling pathway of 20E (20E-GPCR pathway). 20E binds to GPCRs to activate Gαs and Gαq, respectively, to trigger a further signal cascade (1). 20E via Gαq and PLC activates STIM to induce SOCE to activate PKC, which induces USP phosphorylation and acetylation to form the P-EcR/P-USP-Ac transcription complex that promotes 20E pathway gene expression (2). 20E via Gαs and PKA enhances gene transcription (3). 20E regulates β-arrestin-1 and GRK2 phosphorylation and cell membrane migration to induce GPCR internalization or desensitization to terminate 20E signaling via a negative feedback mechanism (4)

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Cell Communication and Signaling

ISSN: 1478-811X