Fig. 5
From: Eukaryotic translation initiation factors as promising targets in cancer therapy
The direct inhibitors of translation apparatus. The structures of compounds are derived from PubChem. BTdCPU is an activator of HRI which can phosphorylate eIF2α. Salubrinal and guanabenz are inhibitors of phosphatase and inhibit eIF2α dephosphorylation. NSC119889 and NSC119893 are direct inhibitors of eIF2-GTP-Met-tRNAiMet ternary complex and prevent the binding of tRNAiMet to eIF2. Hippuristanol, pateamine A and silvestrol are inhibitors of eIF4A. Elatol is an eIF4A-specific inhibitor. 4EGI-1, 4E1RCat and 4E2RCat are inhibitors of eIF4E-eIF4G association