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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Kinase shRNA screening reveals that TAOK3 enhances microtubule-targeted drug resistance of breast cancer cells via the NF-κB signaling pathway

Fig. 4

TAOK3 expression altered cell death in taxane-treated cells. a. Caspase-3 activity was measured at 24 h after paclitaxel treatment using Caspase-Glo 3/7 assay in AU565 and MB157 cells with TAOK3 knockdown. The relative caspase activity was calculated using the bioluminescence value divided by the value of cell viability reading from AlamarBlue. b The relative caspase-3 activity in TAOK3-modified MB157 and BT483 cells treated with paclitaxel. * indicates p-values < 0.05. c The distribution of sub-G1 percentage in TAOK3-modified MB157 cells treated with paclitaxel for 24 h. The TAOK3 expression panel was detected by western blotting. d Expression of TAOK3, cleaved caspase-3, and PARP in Hs578T cells treated by paclitaxel for 24 h

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Cell Communication and Signaling

ISSN: 1478-811X