Table 1 Fold change for pAkt and pMEK in response to varying ligand concentration
From: ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
|  | 0.01 nM VEGF (nM) | 1 nM VEGF a (nM) | Fold change (comparing the two ligand concentrations) | 0.01 nM FGF (nM) | 0.4 nM FGF b (nM) | Fold change (comparing the two ligand concentrations) |
|---|---|---|---|---|---|---|
Doubly phosphorylated Akt | ||||||
 Baseline model | 4.88 × 10−1 | 1.91 × 102 | 3.92 × 102 | 7.75 × 102 | 1.08 × 103 | 1.39 |
 Increase association rate of doubly phosphorylated Akt and PP2A | 3.94 × 10−3 | 2.38 × 101 | 6.03 × 103 | 3.13 × 102 | 5.45 × 102 | 1.74 |
 Remove PP2A negative feedback mediated by ppAkt | 4.96 × 10−1 | 1.69 × 103 | 3.41 × 103 | 2.33 × 103 | 2.35 × 103 | 1.01 |
 Increase association rate and remove negative feedback | 3.94 × 10−3 | 3.96 × 102 | 1.00 × 105 | 2.31 × 103 | 2.34 × 103 | 1.01 |
Doubly phosphorylated MEK | ||||||
 Baseline model | 4.33 × 10−6 | 2.10 × 10−1 | 4.86 × 104 | 2.48 × 101 | 5.27 × 101 | 2.12 |