Autophagy in cancers including brain tumors: role of MicroRNAs

Pourhanifeh, Mohammad Hossein; Mahjoubin-Tehran, Maryam; Karimzadeh, Mohammad Reza; Mirzaei, Hamid Reza; Razavi, Zahra Sadat; Sahebkar, Amirhossein; Hosseini, Nayyerehsadat; Mirzaei, Hamed; Hamblin, Michael R.

doi:10.1186/s12964-020-00587-w

Cell Communication and Signaling

Table 1 Selected autophagy-associated miRNAs in cancer

From: Autophagy in cancers including brain tumors: role of MicroRNAs

Cancer	MicroRNA	Target (s)	Effect (s)	Cell line (s)	Ref
Melanoma	miR-290-295	ATG7, ULK1	Inhibit autophagy	R2L, B16F1	[100]
Melanoma	miR-638	TP53INP2	Inhibit autophagy	SK-Mel-147, SK-Mel-28	[143]
Esophageal cancer	miR-193b	STMN1	Activate autophagy	KYSE450	[144]
Esophageal cancer	miR-634	BIRC5, XIAP, APIP, TFAM, OPA1, LAMP2	Inhibit autophagy	KYSE850	[145]
Squamous cell carcinoma	miR-374a	ATG5, UVRAG	Inhibit autophagy	JHU-029	[146]
	miR-630	UVRAG, ATG12	Inhibit autophagy	JHU-029	[146]
	miR-519a	BECN1, ATG16L1, ATG10	Inhibit autophagy	JHU-029	[146]
	miR-885-3p	AKT1, ULK2, ATG16L2, BCL-2	Inhibit autophagy	JHU-029	[147]
Colorectal cancer	miR-18a	hnRNPA1	–	HCT116, SW620	[148]
	miR-22	BTG1	Inhibit autophagy	RKO, SW620	[149]
	miR-93	ATG16L1	Inhibit autophagy	HCT116	[150]
	miR-106	ATG16L1	Inhibit autophagy	HCT116	[150]
	miR-183	UVRAG	Inhibit autophagy	HT29, HCT116	[151]
	miR-409-3p	BECN1	Inhibit autophagy	LovoOxa R	[152]
	miR-502	RAB1B	Inhibit autophagy	HCT116	[153]
Gastric cancer	miR-143	GABARAPL1	Inhibit autophagy	MKN28, AGS	[154]
Gastric cancer	miR-181a	ATG5	Inhibit autophagy	SGC7901/CDDP	[155]
Lung cancer	miR-7	EGFR	Activate autophagy	A549, H1299	[156]
	miR-16	BCL-2	Inhibit autophagy	A549-T24	[157]
	miR-17-5p	BECN1	Inhibit autophagy	A549-T24	[105]
	miR-143	ATG2B	Inhibit autophagy	H1299	[158]
	miR-144	TIGAR	Activate autophagy	H460, A549	[159]
	miR-200b	ATG12	Inhibit autophagy	H1299/DTX, SPC-A1/DTX	[160]
	miR-216b	BECN1	Inhibit autophagy	Calu-3, A549	[161]
	miR-451	RAB14	–	A549, NCI-H520, SPC-A1	[162]
	miR-487b-5p	LAMP2	Inhibit autophagy	H1299, A549	[163]
Breast cancer	miR-25	ULK1	Inhibit autophagy	MCF-7	[102]
	miR-181a	ATG5	Inhibit autophagy	MCF-7	[119]
	miR-199A-5p	BECN1, DRAM1	Inhibit autophagy	MDA-MB-231, MCF-7	[164]
	miR-200c	UBQLN1	Activate autophagy	MDA-MB-231	[165]
	miR-372	SQSTM1	Inhibit autophagy	MCF10A, MCF-7	[166]
	miR-376b	ATG4C, BECN1	Inhibit autophagy	MCF-7	[113]
	miR-451a	–	Inhibit autophagy	LCC2, MCF-7	[167]
Ovarian cancer	miR-152	ATG14	Inhibit autophagy	SKOV3/DDP, A2780/CP70	[168]
Ovarian cancer	miR-373	RAB22A	Inhibit autophagy	SKOV3	[169]
Cervical cancer	miR-15a/16	RICTOR	Activate autophagy	HeLa	[170]
	miR-20a	ATG7	–	SiHa	[171]
	miR-155	RHEB, RPS6KB2, RICTOR	Activate autophagy	HeLa, NSE	[127]
	miR-224-3p	FIP200	Inhibit autophagy	SiHa, HeLa, C33A	[172]
Endometrial carcinoma	miR-218	HMGB1	Inhibit autophagy	RL95–2	[173]
Prostate cancer	miR-96	ATG7, mTOR	Inhibit autophagy	LAPC4, 22Rv1, LNCaP	[174]
Prostate cancer	miR-124	PIM1	Inhibit autophagy	PC3, DU145	[175]
Liver cancer	miR-21	PTEN	Inhibit autophagy	HepG2, Huh7	[176]
	miR-101	EZH2	Inhibit autophagy	HepG2	[177]
	miR-199A-5p	ATG7	Inhibit autophagy	HepG2, Huh7	[178]
	miR-224	SMAD4	Inhibit autophagy	Hbx, Hep3B	[179]
	miR-375	ATG7	Inhibit autophagy	Hep3B, Huh7	[114]
	miR-376b	ATG4C, BECN1	Inhibit autophagy	Huh7	[113]
Pancreatic cancer	miR-23a	ATG12	Inhibit autophagy	BxPC3	[180]
Pancreatic cancer	miR-216a	BECN1	Inhibit autophagy	PANC-1	[181]
Kidney cancer	miR-214	LC3B, LC3A	Inhibit autophagy	A498, 786-O, Caki-1	[182]
Thyroid cancer	miR-9-3p	ATG5	Inhibit autophagy	MZ-CRC-1, TT	[183]
Hepatocellular carcinoma	miR-17	PTENP1, PTEN	Activate autophagy	Mahlavu	[184]
	miR-19b	PTENP1, PTEN	Activate autophagy	Mahlavu	[184]
	miR-20a	PTENP1, PTEN	Activate autophagy	Mahlavu	[184]

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