Fig. 2

Identification of candidate targets of CLPTM1L by iTRAQ-based analysis. a Expression levels of CLPTM1L in lung adenocarcinoma compared with normal lung tissues obtained from public databases (Selamat dataset). Student’s t test; ** P < 0.01. b Proteins upregulated or downregulated by CLPTM1L in A549 cells exposed to IR were identified by iTRAQ-based analysis based on the P-value (P < 0.05). c–d Distribution of mass or isoelectric point of the 1237 proteins identified. e–f Analysis of parallelism between CLPTM1L overexpressing groups or control groups from iTRAQ-based analysis. g Volcano plot showing 233 CLPTM1L-modulated genes among the 1237 genes identified based on fold changes in expression [log₁₀(FC) < − 0.14 or log₁₀(FC) > 0.14]