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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Estrogen-ERα signaling and DNA hypomethylation co-regulate expression of stem cell protein PIWIL1 in ERα-positive endometrial cancer cells

Fig. 7

Proposed model of the cooperation between E2-ERα signaling and DNA hypomethylation for the regulation of stem cell protein PIWIL1. upper: In normal cells, hypermethylation of PIWIL1 promoter prevents the binding of E2–ERα complex to PIWIL1 promoter. Lower: In endometrial cancer cells, increased PIWIL1 expression regulated by E2–ERα signaling is due to the cancer-linked hypomethylation of the PIWIL1 promoter

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Cell Communication and Signaling

ISSN: 1478-811X