Table 3 LncRNAs involved in the regulation of cardiac fibrosis mediated by TGFβ/WNT signaling pathways
From: TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus
LncRNAs | Expression (up/down) | Function | Model | Anti- fibrotic or Pro-fibrotic | Reference |
|---|---|---|---|---|---|
n379519 | Up | Sponged miR-30/Activated TGFβ signaling pathway | TGFβ MI/ Rat CFs | Pro | [196] |
Taurine Upregulated Gene 1 (TUG1) | Up | Sponged miR-29c/Activated TGFβ signaling pathway | Congenital human heart tissue, chronic hypoxic mouse CFs | Pro | [197] |
Homeobox A11 antisense (HOXA11-AS) | Up | Activated TGFβ signaling pathway | Mouse CFs | Pro | [198] |
Colorectal neoplasia differentially expressed (Crnde) | Down | Inhibited the binding of Smad3 to the α-SMA gene promoter via interacting with rSBEs | DCM/Human, mouse/CFs | Anti | [199] |