Table 5 Cell cycle, DNA replication and mismatch repair genes negatively correlated to DLG2 expression, common to NB primary datasets 1–3 (GSE49710, GSE16476 and GSE89413) and the human embryogenesis dataset (GSE15744)
Gene symbol | Gene function | Cellular process |
|---|---|---|
BUB1, BUB1B | Mitotic checkpoint serine/threonine kinase | Mitotic checkpoint |
CCNA2 | Cyclin A2, G1/S to G2/M transition | Cell cycle regulation |
CCNB1 | Cyclin B1, G2/M transition | Cell cycle regulation |
CDC20 | Cell division, anaphase regulation | Chromosome separation |
CDK4 | Cyclin dependent kinase, G1/S phase | Cell cycle regulation |
DBF4 | E2F mediated regulation of DNA replication | DNA replication |
ESPL1 | Sister chromatid cohesion and separation | Chromosome separation |
EXO1 | Exonuclease 1 | DNA repair |
LIG1 | DNA ligase, DNA replication and repair | DNA replication |
MCM2, MCM3, MCM5, MCM7 | Initiation of genome replication | DNA replication |
MSH6 | Mismatch recognition | DNA repair |
POLD2 | DNA polymerase delta | DNA replication |
PRKDC | DNA-dependent protein kinase | DNA repair |
POLA1, POLA2 | DNA polymerase alpha | DNA replication |
RFC3, RFC4 | Replication factor, DNA elongation | DNA replication |
TP53 | Tumor suppressor, DNA binding | Cell cycle regulation |