Fig. 7
Knockdown of miR-153 attenuates learning and memory deficits in the 2VO model. a Knockdown of miR-153 by injecting lenti-AMO-153 reversed the increase in the daily average escape latency to locate the platform from three nontarget quadrants in 2VO rats. χ2Mauchly = 16.20, P = 0.063;; Ftotal (4, 104) = 7.404, P = 0.001. b Average number of platform crossings during the probe trial. PLevene = 0.005, one-way ANOVA: F = 4.736, P = 0.008. n = 8, *P < 0.05 vs lenti-NC; #P < 0.05 vs 2VO + lenti-AMO-153. One-way ANOVA, Fisher’s PLSD test were used for the post hoc analyses of the two-group comparisons. c Represent path tracing of the probe trial test on day 6 in the MWM test for each group