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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer

Fig. 4

Effects of C-myc inhibitor 10,058-F4 on HT29 and DLD1 cells. a HT29 and DLD1 cells were treated with various concentrations of 10,058-F4 for 48 h and analyzed using the MTT assay. HT29 and DLD1 cells were treated with 50 μmol/l of 10,058-F4 for the indicated time and analyzed using the MTT assay; b, c HT29 and DLD1 cells were treated with 10,058-F4 for 48 h and analyzed using the flow cytometry for cell cycle analysis; d, e HT29 and DLD1 cells were treated with 10,058-F4 for 48 h and analyzed using the flow cytometry for the Annexin V-PI analysis; f Expression of the CIP2A, C-myc, Bcl-2, Bax, Cyclin D1, p21 and p27 proteins in CRC cells treated with 10,058-F4 was detected by western blotting. *P < 0.05 compared to the control using Student’s t-test

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Cell Communication and Signaling

ISSN: 1478-811X