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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Activation of the PDGFRα-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking Nck1

Fig. 3

Nck1 deletion leads to Nrf2 activation in BM-MSCs. a Western blots of Nrf2 and quantification relative to Hsp90 in growing Nck1+/+ and Nck1−/− BM-MSCs isolated from week 5 post-weaning mice (n = 3/group). b Relative Nqo1 and Hmox1 mRNA levels in growing Nck1+/+ and Nck1−/− BM-MSCs isolated from week 5 post-weaning (W5) and week 20 post-weaning (W20) mice (n = 3–4/group). Data are mean ± SEM. Statistical significance evaluated by unpaired Student’s t-test and is reported as *p ≤ 0.05

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