Fig. 7
From: FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer
FOXE1 is a transcription factor of HK2. a Luciferase activity of the pGL3-HK2-Luc in HCT116 and LoVo cells being transfected with FOXE1 plasmid. b The truncated HK2 promoter regions were cloned into the pGL3 plasmid. c Enhanced FOXE1 expression strongly enhanced the promoter activity of the P1 but not the P2, P3 and P4 regions. d ChIP assays performed in HCT116 and LoVo cells. Specific anti-Flag antibody for ectopically expressed Flag-FOXE1, but not isotype IgG, captured the fragment that possibly containing the FOXE1 response element in the HK2 promoter region. *P < 0.05