Fig. 3

Targeting Hh signaling at different levels of the cascade. Hh ligand antibody, e.g., 5E1, blocks interaction of Hh ligand and receptor. SMO inhibitors, e.g., cyclopamine, directly bind to and inactivate SMO. GLI1 inhibitors, e.g., GANT61, interrupt transcriptional activity of GLI1 by directly binding to GLI1. BET inhibitor JQ1 represses Hh signaling by interfering with the regulation of BRD4 on GLI1/GLI2