Fig. 3

MORC2 promotes the recruitment of DNA repair proteins to DNA damage sites and cell survival in response to DNA damage. a-b WT and MORC2 KO HeLa (a) or MCF-7 (b) cells were treated with 8 μM CPT for 1 h. Immunofluorescent staining was carried out with the indicated antibodies. Quantitative results were determined by the average foci from 8 representative cells. c-d WT and MOCR2 KO HeLa (c) and MCF-7 (d) cells were treated with or without 4 μM CPT and were subjected to clonogenic survival assays. **, p < 0.01