Table 1 Combined elevated GREM1 and BMP expression level improves prognostic value in ER-negative breast cancer patients. Analysis of RFS in breast cancer patients using KM plotter. High and low expression were defined as above and below median
Gene(s) | Gene ID | all BC patients | ER+ BC patients | ER- BC patients | |||
|---|---|---|---|---|---|---|---|
HR | p-value | HR | p-value | HR | p-value | ||
GREM1 | 218469_at | 1.32 (1.18–1.47) | 6.90E-07 | 1.19 (1.01–1.4) | 0.035 | 1.51 (1.2–1.9) | 0.00037 |
BMP2 | 205289_at | 0.88 (0.79–0.98) | 0.02 | 0.88 (0.75–1.04) | 0.13 | 1.01 (0.81–1.26) | 0.94 |
BMP4 | 211518_s_at | 0.9 (0.81–1) | 0.058 | 0.98 (0.83–1.16) | 0.83 | 1.16 (0.93–1.46) | 0.19 |
BMP7 | 209590_at | 0.88 (0.79–0.98) | 0.023 | 1.08 (0.92–1.27) | 0.36 | 0.92 (0.73–1.15) | 0.45 |
BMP2/GREM1 | 205289_at / 218469_at | 1.33 (1.19–1.48) | 3.70E-07 | 1.21 (1.03–1.42) | 0.022 | 1.64 (1.31–2.07) | 1.80E-05 |
BMP4/GREM1 | 211518_s_at / 218469_at | 1.28 (1.15–1.43) | 7.30E-06 | 1.2 (1.02–1.42) | 0.026 | 1.63 (1.3–2.06) | 2.30E-05 |
BMP7/GREM1 | 209590_at / 218469_at | 1.29 (1.16–1.44) | 4.10E-06 | 1.19 (1.01–1.4) | 0.04 | 1.63 (1.3–2.06) | 2.30E-05 |