Skip to main content
Fig. 2 | Cell Communication and Signaling

Fig. 2

From: GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients

Fig. 2

BMP-antagonists are genetically altered in a high frequency of breast cancer biopsies. (a) Heat-map showing the RNA-seq expression levels of 11 BMP-antagonists (cut-off: expression level ≥ 1 in either in vitro cultivated cells or tumors of 67NR and 66cl4). Values are given in fragments per kilobase of transcripts per million fragments mapped (FPKM). (b) Gene enrichment analysis of the 1252 genes significantly upregulated in 67NR cells and primary tumors using the Enrichr online tool (TRANSFAC and JASPAR position weight matrices). (c) Genetic alterations in extracellular, intracellular and transmembrane BMP-antagonists, as well as BMP2, BMP4 and BMP7 were analyzed using cBioPortal in 960 patient samples from The Cancer Genome Atlas (TCGA) provisional data set for invasive breast carcinoma

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X