Fig. 6
From: Notch pathway: a bistable inducer of biological noise?
Noise-induced bistability and resolution of fate dichotomies. a Integrated view of global network topology of Wnt/PI3K/Myc axis following integration of the Notch signaling pathway. b It is proposed that Notch signaling input combines enhanced autophagic flux with amplifications of translational noise in order to destabilize the existing cellular memory (i.e. destabilize thermodynamic stability) and to invoke bistability prior to biological decision-making. Resolution of such bistability requires integration of exogenous cues that amplify or terminate the Notch signalling pathway