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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk

Fig. 5

Quantification of transferred and control transcripts’ expressions in endometrial cells. Expressions of (a) Intronic-region of LINC00478, (b) Exonic region of LINC00478, (c) ZNF81, (d) beta actin and (e) beta-2-microglobulin in endometrial cells in co-culture with trophoblast spheroids, co-culture with HEK293 spheroids, treated with JAr derived extracellular vesicles (EVs), treated with HEK293 derived EVs and untreated control. Spheroids were co-incubated with endometrial cell monolayer for 24 h. Isolated EVs were incubated with endometrial cells for 24 h. Whole RNA of endometrial cells was quantified using qPCR for expression of transferred/control transcripts. Data is presented as mean ± SEM. (*) p < 0.05 vs untreated control

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Cell Communication and Signaling

ISSN: 1478-811X