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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma

Fig. 1

Cell viability and combination index by MTT assay testing single or combination treatment. a-c The effect in cell viability of the combination of the PAK inhibitor IPA-3 and the PKCι inhibitor auranofin was assessed by MTT assay in HCC827, H23 and H520 cell lines. The experiments were performed by triplicate. Drug concentration was increased gradually from 0 to 3 times of IC50. Cell viability on combination treatment (green line) was decreased significantly in comparison to single drug treatment (red and blue line). d-e Range of combination index of combination treatment on each cell line. Gray part is the area corresponding to addictive interaction. The combination of IPA-3 plus auranofin was synergic and showed lowest combination index (0.34–0.39) in 3 cell lines. IPA-3 plus midostaurin was synergic only in HCC827 and IPA-3 plus osimertinib was synergic only in H23

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Cell Communication and Signaling

ISSN: 1478-811X