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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: CXCL1-LCN2 paracrine axis promotes progression of prostate cancer via the Src activation and epithelial-mesenchymal transition

Fig. 6

Src family kinases activation in CXCL1 or LCN2 treated prostate cancer cells mediates cancer cells migration. a Representative images (magnification 40X) of prostate cancer cells migration after treatment of CXCL1 or LCN2 with or without SFKs inhibitor PP2. Histograms shows quantitative results from three times experiments and p value was determined by Student’s t test. b Phosphorylation of Src-FAK-Paxillin in DU145 after treatment of CXCL1 or LCN2 with or without supplement of PP2 was detected using western blotting. c Representative cells migration images (magnification 40X) of DU145 stimulated with CXCL1 or LCN2 in addition of β-Catenin inhibitor XAV939. d Expression of EMT markers in DU145 after CXCL1/LCN2 treatment was determined using western blotting

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Cell Communication and Signaling

ISSN: 1478-811X