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Table 2 CXCL12 effect on invasion by colon cancer cells

From: Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling

Cell line

Relative number of invading cells (%)

Untreated

with FB

CXCL12 (ng/ml)

1

10

100

HT-29

100 ± 9.2

136.2 ± 10.3*

112.3 ± 8.60

132.7 ± 11.3*

162.0 ± 13.4*

CaCo-2

100 ± 11.5

139.3 ± 11.7*

109.3 ± 11.4

136.9 ± 10.5*

152.0 ± 13.9*

Colo320

100 ± 11.1

143.5 ± 12.9*

107.5 ± 10.0

127.5 ± 12.9*

148.4 ± 17.5*

  1. NOTE: Colon cancer cells were treated with different concentrations of CXCL12 and incubated for 24 h. Cell invasion was then measured by the Matrigel assay. Statistical significance was tested by one-way ANOVA followed by the Dunnett test. Statistical significance was inferred if p < 0.05. All data are expressed as mean ± s.d. *p < 0.01 when compared with untreated cells
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Cell Communication and Signaling

ISSN: 1478-811X