Fig. 7
Model of mutant KIT trafficking and signals on the Golgi in leukemia cells. Newly synthesized mutant KIT (KITN822K or KITV560G) in the ER traffics to the PM through the Golgi apparatus. They are normally complex-glycosylated in the Golgi. After reaching the PM, mutant KIT immediately undergoes endocytosis in a manner dependent on its kinase activity, then accumulates in EL. However, its full autophosphorylation mainly occurs on the Golgi, where it causes downstream activation. Lipid rafts play a role in KIT signaling. ER-localized KIT is inactivated by PTPs