Fig. 4
GlaB and GlaB/ACCA treatment in vivo is effective in glioma-bearing mice. a Extraction chromatograms (XIC) referred to brain extract of GlaB IN treated mice (a) and vehicle mice (b). GlaB peak at known retention time (Rt) of 25.00 min is shown and detected in IN treated sample and is missing in control. * The peak at Rt: 23.90 min is the isotopic abundance with m/z = 451 of an unknown peak with m/z = 449, present in all brain extracts. b Tumor volume (mm3) in GL261-bearing mice intra-nasally treated with GlaB (PEG-Cholane GlaB 1.44 mg/Kg), GlaB+ACCA (6 μl 33 mm) or vehicle (PEG-Cholane). Data are expressed as mean ± se, *p < 0.05 vs control, #p < 0.05 vs GlaB, One-way ANOVA n = 8