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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: The critical role of RasGRP4 in the growth of diffuse large B cell lymphoma

Fig. 4

MAPK-associated signaling pathways downstream of RasGRP4 are involved in DLBCL. (a) Representative WB images showing the differences in expression and phosphorylation levels of the downstream signaling proteins between SUDHL-4 cells and normal/activated B cells. (b and c) Quantification of the levels (in a) and the phosphorylation ratio (in a). Compared with normal/activated B cells, the ratios of P-ERK1/2:ERK1/2 and P-ERK5:ERK5 were increased in DLBCL cells, while the ratio of P-JNK:JNK was decreased, and no significant change in the P-P38:P38 ratio was detected. (d) Representative WB images showing the differences in expression and phosphorylation levels of the downstream signaling proteins in RasGRP4-knockdown SUDHL-4 cells and the control group. (e and f) Quantification of the levels (in d) and the phosphorylation ratio (in d). Knockdown of RasGRP4 decreased the ERK expression and increased the JNK expression in SUDHL-4 cells; densitometry was analyzed using ImageJ software. N indicates the number of independent experiments. **P < 0.01, *P < 0.05

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