Fig. 5
From: Wnt signaling: a promising target for osteoarthritis therapy
![Fig. 5](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12964-019-0411-x/MediaObjects/12964_2019_411_Fig5_HTML.png)
Interaction within TGF-b/BMP, canonical and non-canonical signaling pathway in osteoblast, in addition to induces DKK2 to inhibit the canonical Wnt signaling pathway, TGF-b/BMP signaling also up-regulates the expression of Wnt5a In osteoblasts, and subsequently stimulating the expression of a number of genes involved with osteogenesis