Fig. 2
From: Wnt signaling: a promising target for osteoarthritis therapy
The signaling transduction cascades and cell-specific role of noncanonical Wnt signaling, predominantly activated by wnt5a, in regulating chondrocyte, synovial cells, osteoblast and osteoclast metabolism, including mediated IL-1 beta stimulated chondrocyte catabolism, TNF-alpha and IL-17A induced synovium inflammation, as well abnormal mineralization of osteoblast and osteoclast differentiation, all these process are promised to be involved in OA development